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Anlotinib Dihydrochloride

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Anlotinib Dihydrochloride
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1875Check With Us
200mg$2812Check With Us
500mg$4745Check With Us
email: [email protected]        [email protected]

Cat #: V3286 CAS #: 1360460-82-7 (di-HCl); Purity ≥ 98%

Description: Anlotinib Dihydrochloride (formerly known as AL3818 Dihydrochloride) is a novel and potent multi-kinase inhibitor that inhibits VEGFR2/3, FGFR1-4, PDGFRα/β, c-Kit, and Ret.

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Molecular Weight (MW)480.36
Molecular FormulaC23H24Cl2FN3O3
CAS No.1360460-82-7 (di-HCl);
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 60 mg/mLr
Water:r
Ethanol:
SMILES CodeNC1(COC2=C(OC)C=C3C(OC4=C(F)C5=C(NC(C)=C5)C=C4)=CC=NC3=C2)CC1.[H]Cl.[H]Cl
SynonymsAL3818 dihydrochloride; AL-3818 dihydrochloride; AL 3818 dihydrochloride; Anlotinib HCl;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.0818 mL10.4089 mL20.8177 mL41.6354 mL
5mM0.4164 mL2.0818 mL4.1635 mL8.3271 mL
10mM0.2082 mL1.0409 mL2.0818 mL4.1635 mL
20mM0.1041 mL0.5204 mL1.0409 mL2.0818 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.