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| Size | Price | Stock |
|---|---|---|
| 100mg | $1040 | Check With Us |
| 250mg | $1800 | Check With Us |
| 500mg | $2700 | Check With Us |
: Cat #: V4506 CAS #: 943540-74-7 Purity ≥ 98%
Description: OMO-1 (formerly known as JNJ-38877618) is a novel, potent, highly selective and orally bioavailable Met kinase inhibitor with nM binding affinity (Kd=1.4 nM) and enzyme inhibitory activity against wt and M1268T mutant MET (IC50 2 and 3 nM ).
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- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 374.35 |
|---|---|
| Molecular Formula | C20H12F2N6 |
| CAS No. | 943540-74-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | FC(C1=CC=C2N=CC=CC2=C1)(F)C3=NN=C4C=CC(C5=CC=NC=C5)=NN43 |
| Synonyms | JNJ-38877618; JNJ 38877618; JNJ38877618 |
| Protocol | In Vitro | OMO-1 (formerly JNJ-38877618), is a potent, highly selective, orally bioavailable Met kinase inhibitor with nM binding affinity (Kd=1.4 nM) and enzyme inhibitory activity against wt and M1268T mutant Met (2 and 3 nM IC50). Met inhibitory effects are assessed in proliferation, colony formation and motility assays. JNJ-38877618 displays nM potency against Met Ampl/mutant and therapy resistant models. |
|---|---|---|
| In Vivo | JNJ-38877618 induces complete inhibition of tumor growth in 3 models: the SNU5 Met amp gastric, U87-MG HGF autocrine glioblastoma and Hs746T Met exon 14 skipping mutant gastric cancer. JNJ-38877618 induces regression of large Met amplified EBC-1 SqNSCLC where JNJ-38877618 leads to dose- and time-dependent inhibition of Met kinase activation, with the duration of target shut down considerably exceeding plasma exposure times. Combination treatments are well tolerated and improved EGFR targeted therapy. |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6713 mL | 13.3565 mL | 26.7130 mL | 53.4259 mL |
| 5mM | 0.5343 mL | 2.6713 mL | 5.3426 mL | 10.6852 mL |
| 10mM | 0.2671 mL | 1.3356 mL | 2.6713 mL | 5.3426 mL |
| 20mM | 0.1336 mL | 0.6678 mL | 1.3356 mL | 2.6713 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.