HG-14-10-04 | CAS 1356962-34-9

HG-14-10-04

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$520	In Stock
250mg	$850	In Stock
500mg	$1275	In Stock

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Cat #: V3374 CAS #: 1356962-34-9 Purity ≥ 98%

Description: HG-14-10-04 is a novel, potent and specific ALK (Anaplastic lymphoma kinase) inhibitor with IC50 of 20 The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the development of the brain and can be oncogenically altered in several malignancies, including non-small-cell lung cancer (NSCLC) and anaplastic large cell lymphomas (ALCL).

References: U.S. Pat. Appl. Publ. (2012), US 20120028924 A1

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	532.08
Molecular Formula	C29H34ClN7O
CAS No.	1356962-34-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	CN1CCN(C2CCN(C3=CC=C(NC4=NC=C(Cl)C(C5=CNC6=C5C=CC=C6)=N4)C(OC)=C3)CC2)CC1
Synonyms	HG-14-10-04; HG 14-10-04; HG14-10-04; HG-141004; HG 141004; HG141004;

Protocol	In Vitro	HG-14-10-04 (example 10) has inhibitory activity against ALK kinase with an IC50 of 20 nM.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8794 mL	9.3971 mL	18.7942 mL	37.5883 mL
5mM	0.3759 mL	1.8794 mL	3.7588 mL	7.5177 mL
10mM	0.1879 mL	0.9397 mL	1.8794 mL	3.7588 mL
20mM	0.0940 mL	0.4699 mL	0.9397 mL	1.8794 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.