FGFR4-IN-1 | CAS 1708971-72-5

FGFR4-IN-1

This product is for research use only, not for human use. We do not sell to patients.

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250mg	$1450	Check With Us
500mg	$2050	Check With Us
1g	$3075	Check With Us

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Cat #: V21016 CAS #: 1708971-72-5 Purity ≥ 98%

Description: FGFR4-IN-1 is a potent and selective FGFR4 inhibitor. FGFR4 may be a novel therapeutic target for gastric cancer.

References: Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO 2015059668 A1?

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	493.52
Molecular Formula	C24H27N7O5
CAS No.	1708971-72-5
SMILES Code	O=C(N1CCCC2=CC(CN3C(COCC3)=O)=C(C=O)N=C12)NC4=NC=C(C#N)C(NCCOC)=C4
Synonyms	FGFR4-IN-1; FGFR4-IN1; FGFR4-IN 1

Protocol	In Vitro	FGFR4-IN-1 significantly inhibits the proliferation of HuH-7 hepatocellular carcinoma cells with IC50 of 7.8 nM.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0263 mL	10.1313 mL	20.2626 mL	40.5252 mL
5mM	0.4053 mL	2.0263 mL	4.0525 mL	8.1050 mL
10mM	0.2026 mL	1.0131 mL	2.0263 mL	4.0525 mL
20mM	0.1013 mL	0.5066 mL	1.0131 mL	2.0263 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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