Gambogenic Acid

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$1725	Check With Us
200mg	$2587	Check With Us
500mg	$4365	Check With Us

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Cat #: V10988 CAS #: 173932-75-7 Purity ≥ 98%

Description: Gambogenic Acid, a naturally occuring ingredient dound in gamboge, is a potent inhibitor of the fibroblast growth factor receptor (FGFR) signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC).

References: Wang X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May 2;36(9):1243-1260.

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	630.77
Molecular Formula	C38H46O8
CAS No.	173932-75-7
SMILES Code	O=C(O)/C(C)=CC[C@]([C@@]12OC3=C4C(O)=C(C/C=C(C)/CC/C=C(C)C)C(O)=C3C/C=C(C)C)(OC(C)(C)[C@]2([H])C5)C([C@]5([H])C=C1C4=O)=O
Synonyms	Gambogenic Acid; GNA;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5854 mL	7.9268 mL	15.8536 mL	31.7073 mL
5mM	0.3171 mL	1.5854 mL	3.1707 mL	6.3415 mL
10mM	0.1585 mL	0.7927 mL	1.5854 mL	3.1707 mL
20mM	0.0793 mL	0.3963 mL	0.7927 mL	1.5854 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.