Picropodophyllin (Picropodophyllotoxin, AXL-1717 or PPP)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$1150	Check With Us
1g	$1850	Check With Us
5g	$7025	Check With Us

: [email protected] [email protected]

Cat #: V0628 CAS #: 477-47-4 Purity ≥ 98%

Description: Picropodophyllin (also known as Picropodophyllotoxin, AXL1717 or PPP), a naturally occuring cyclolignan alkaloid isolated from the mayapple plant family, is a novel, potent, orally bioavailable and selective small molecule inhibitor of the IGF-1R with potential antineoplastic activity.

References: Girnita A, et al. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004 Jan 1;64(1):236-42.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	414.41
Molecular Formula	C22H22O8
CAS No.	477-47-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 82 mg/mL (197.9 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	1% CMC Na: 30 mg/mL
SMILES Code	O=C1OC[C@]2([H])[C@@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(OC)C(OC)=C5)[C@@]21[H]
Synonyms	Picropodophyllotoxin, AXL1717; PPP; AXL-1717; AXL 1717; PPP; picropodophyllin;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4131 mL	12.0653 mL	24.1307 mL	48.2614 mL
5mM	0.4826 mL	2.4131 mL	4.8261 mL	9.6523 mL
10mM	0.2413 mL	1.2065 mL	2.4131 mL	4.8261 mL
20mM	0.1207 mL	0.6033 mL	1.2065 mL	2.4131 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.