AG-1024 (Tyrphostin; Tyrphostin AG1024)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1250 | Check With Us |
| 1g | $1800 | Check With Us |
| 5g | $4555 | Check With Us |
: Cat #: V0626 CAS #: 65678-07-1 Purity ≥ 98%
Description: AG-1024 (also called Tyrphostin or Tyrphostin AG1024) is a potent and selective inhibitor of IGF-1R (insulin-like growth factor-1) with potential antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 305.17 |
|---|---|
| Molecular Formula | C14H13BrN2O |
| CAS No. | 65678-07-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 61 mg/mL (199.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL |
| SMILES Code | N#C/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(Br)=C1 |
| Synonyms | Tyrphostin, AG-1024; AG 1024; AG1024; Tyrphostin AG1024; Tyrphostin AG-1024 |
| Protocol | In Vitro | AG1024 (2 μM; 6, 12 hours) downregulates phospho-Akt, Bcr-Abl and upregulates DNA-PKcs. AG1024 (1-5 μM; 1-3 days) induces UT7-9 and Baf3-p210 cells apoptosis. AG1024 (Tyrphostin AG 1024; 2-10 μM; 1-5 days) shows a dose-dependent inhibition of cell proliferation. |
|---|---|---|
| In Vivo | AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2769 mL | 16.3843 mL | 32.7686 mL | 65.5372 mL |
| 5mM | 0.6554 mL | 3.2769 mL | 6.5537 mL | 13.1074 mL |
| 10mM | 0.3277 mL | 1.6384 mL | 3.2769 mL | 6.5537 mL |
| 20mM | 0.1638 mL | 0.8192 mL | 1.6384 mL | 3.2769 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.