Home > Signaling Pathways>Angiogenesis>Syk>Lanraplenib succinate (GS9876; GS-SYK)
Lanraplenib succinate (GS9876; GS-SYK)

This product is for research use only, not for human use. We do not sell to patients.

Lanraplenib succinate (GS9876; GS-SYK)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1750To Be Confirmed
250mg$2950To Be Confirmed
500mg$4425To Be Confirmed
email: [email protected]        [email protected]

Cat #: V40855 CAS #: 1800047-00-0 Purity ≥ 99%

Description: Lanraplenib (also known as GS-9876; GS-SYK) is a highly selective and orally bioavailable Spleen Tyrosine Kinase (SYK) inhibitor with IC50 of 9.5 nM).

References: Di Paolo J, et al. FRI0049 Preclinical Characterization of GS-9876, A Novel, Oral SYK Inhibitor That Shows Efficacy in Multiple Established Rat Models of Collagen-Induced Arthritis.Annals of the Rheumatic Diseases 2016;75:443-444.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)620.64
Molecular FormulaC23H25N9O.3/2C4H6O4
CAS No.1800047-00-0
SMILES CodeNc1cncc(n1)c2cn3ccnc3c(Nc4ccc(cc4)N5CCN(CC5)C6COC6)n2.Nc7cncc(n7)c8cn9ccnc9c(Nc%10ccc(cc%10)N%11CCN(CC%11)C%12COC%12)n8.OC(=O)CCC(=O)O.OC(=O)CCC(=O)O.OC(=O)CCC(=O)O
SynonymsGS-SYK, GS-9876; GS 9876; GS9876; Lanraplenib succinate
ProtocolIn VitroLanraplenib succinate (GS-9876 succinate) inhibits anti-IgM stimulated phosphorylation of AKT, BLNK, BTK, ERK, MEK, and PKCδ in human B cells with EC50 values of 24-51 nM. Lanraplenib monosuccinate inhibits anti-IgM mediated CD69 and CD86 expression on B-cells (EC50=112±10 nM and 164±15 nM, respectively) and anti-IgM /anti-CD40 co-stimulated B cell proliferation (EC50=108±55 nM). In human macrophages, Lanraplenib succinate inhibits IC-stimulated TNFα and IL-1β release (EC50=121±77 nM and 9±17 nM, respectively).
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.6112 mL8.0562 mL16.1124 mL32.2248 mL
5mM0.3222 mL1.6112 mL3.2225 mL6.4450 mL
10mM0.1611 mL0.8056 mL1.6112 mL3.2225 mL
20mM0.0806 mL0.4028 mL0.8056 mL1.6112 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.