Fostamatinib disodium hexahydrate

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$925	Check With Us
500mg	$1480	Check With Us
1g	$2220	Check With Us

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Cat #: V3898 CAS #: 914295-16-2 Purity ≥ 98%

Description: Fostamatinib disodium hexahydrate (formerly R-935788; R 935788; R-788; R788; trade name: Tavalisse) is the disodium salt and hexa-hydrated form of Fostamatinib which is a prodrug of the active metabolite R406.

References: Stephen P McAdoo, et al. Fostamatinib Disodium. Drugs Future. 2011;36(4):273.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	732.51
Molecular Formula	C₂₃H₂₄FN₆Na₂O₉P.₆H₂O
CAS No.	914295-16-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 30 mg/mLr
	Water: 6 mg/mLr
	Ethanol: N/A
Solubility In Vivo	0.5% CMC+0.25% Tween 80,pH6.5: 30 mg/mL
SMILES Code	O=P([O-])([O-])OCN1C2=NC(NC3=NC(NC4=CC(OC)=C(OC)C(OC)=C4)=NC=C3F)=CC=C2OC(C)(C)C1=O.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Na+].[Na+]
Synonyms	Fostamatinib disodium hexahydrate; R788 (disodium hexahydrate); Tamatinib Fosdium, R 788; R-935788; R788; R935788; R-935788; R 935788; 788; R-788 sodium. R935788 sodium. Fostamatinib sodium hydrate, prodrug of R-406.

Protocol	In Vivo	Fostamatinib (R788) is highly bioavailable, and rapidly absorbed in Louvain rats. R406 following a single oral dose of R788 10 mg/kg or 20 mg/kg: AUC0-16 hrs= 10618 ngh/mL and 30650 ngh/mL respectively; Cmax=2600 ng/mL and 6500 ng/mL respectively (observed at 1 hour); t1/2=4.2 hours. The prodrug was not detected in plasma suggesting R788 is completely converted to R406.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.3652 mL	6.8258 mL	13.6517 mL	27.3034 mL
5mM	0.2730 mL	1.3652 mL	2.7303 mL	5.4607 mL
10mM	0.1365 mL	0.6826 mL	1.3652 mL	2.7303 mL
20mM	0.0683 mL	0.3413 mL	0.6826 mL	1.3652 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.