Tolimidone (MLR-1023)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $900 | Check With Us |
| 200mg | $1350 | Check With Us |
| 500mg | $2280 | Check With Us |
: Cat #: V16561 CAS #: 41964-07-2 Purity ≥ 98%
Description: Tolimidone, formerly known as MLR-1023, is a novel and potent insulin receptor potentiator, and also a selective allosteric activator of Lyn kinase (EC50 of 63 nM).
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| Molecular Weight (MW) | 202.21 |
|---|---|
| Molecular Formula | C11H10N2O2 |
| CAS No. | 41964-07-2 |
| SMILES Code | O=C1N=CC(OC2=CC=CC(C)=C2)=CN1 |
| Synonyms | Tolimidone; MLR-1023 |
| Protocol | In Vitro | Incubation of Tolimidone (MLR-1023) with Lyn kinase elicits a repeatable 50% increase in enzyme activity. Tolimidone elicits a concentration-dependent increase in Lyn kinase activation with a 2.3- and 2.1-fold increase achieved at concentrations of 3 and 10 μM, respectively. Inclusion of Tolimidone (100 μM) increases Lyn kinase activity by 3-fold at each ATP concentration tested (Vmax=2601 U/mg). Tolimidone-mediated activation of Lyn kinase increases in proportion to the length of preincubation period in the absence of ATP. |
|---|---|---|
| In Vivo | Administration of Tolimidone (MLR-1023) (30 mg/kg i.p.) significantly (p<0.05) lowers blood glucose levels to 148 and 158 mg/dL, 30 and 90 min after administration, respectively. Tolimidone significantly increases adipocyte differentiation and adiponectin production by 3.7- and 19-fold, respectively. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.9454 mL | 24.7268 mL | 49.4535 mL | 98.9071 mL |
| 5mM | 0.9891 mL | 4.9454 mL | 9.8907 mL | 19.7814 mL |
| 10mM | 0.4945 mL | 2.4727 mL | 4.9454 mL | 9.8907 mL |
| 20mM | 0.2473 mL | 1.2363 mL | 2.4727 mL | 4.9454 mL |
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The dilution calculator equation
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Step One: Enter information below
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Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.