Tirbanibulin Mesylate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $890 | Check With Us |
| 500mg | $1350 | Check With Us |
| 1g | $2025 | Check With Us |
: Cat #: V4267 CAS #: 1080645-95-9 Purity ≥ 98%
Description: Tirbanibulin Mesylate (also known as KXO-1 Mesylate and KX2-391 Mesylate) is a tubulin/Src inhibitor that has gained FDA approval in 2020 for the treatment of actinic keratosis on the face or scalp.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 527.63 |
|---|---|
| Molecular Formula | C₂₇H₃₃N₃O₆S |
| CAS No. | 1080645-95-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >80 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| Solubility In Vivo | 4% DMSO+30% PEG 300+ddH2O: 5 mg/mL |
| SMILES Code | O=C(NCC1=CC=CC=C1)CC2=NC=C(C3=CC=C(OCCN4CCOCC4)C=C3)C=C2.OS(=O)(C)=O |
| Synonyms | KXO1 HCl; KX-01, KX 01 HCl; KXO1 HCl; Mesylate; KX-01, KX 01 Mesylate; KX2-391; KX-2-391 Mesylate; KX 2-391; KX2391; KX-2391; KX 2391 Mesylate |
| Protocol | In Vitro | Tirbanibulin Mesylate (KX2-391 Mesylate) is a Src inhibitor that is directed to the Src substrate pocket. Tirbanibulin (KX2-391) shows steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines. |
|---|---|---|
| In Vivo | Orally administered Tirbanibulin Mesylate (KX2-391 Mesylate) is shown to inhibit primary tumor growth and to suppress metastasis, in pre-clinical animal models of cancer. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8953 mL | 9.4763 mL | 18.9527 mL | 37.9054 mL |
| 5mM | 0.3791 mL | 1.8953 mL | 3.7905 mL | 7.5811 mL |
| 10mM | 0.1895 mL | 0.9476 mL | 1.8953 mL | 3.7905 mL |
| 20mM | 0.0948 mL | 0.4738 mL | 0.9476 mL | 1.8953 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.