XL092
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $2250 | Check With Us |
| 500mg | $3500 | Check With Us |
| 1g | $5250 | Check With Us |
: Cat #: V2387 CAS #: 2367004-54-2 Purity ≥ 99%
Description: XL-092 is a novel and potent inhibitor of the activity of Axl, Mer and C-Met kinase .
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 528.53 |
|---|---|
| Molecular Formula | C29H25FN4O5 |
| CAS No. | 2367004-54-2 |
| SMILES Code | O=C(C1(C(NC2=CC=C(OC3=CC=NC4=CC(OC)=C(C(NC)=O)C=C34)C=C2)=O)CC1)NC5=CC=C(F)C=C5 |
| Synonyms | JUN04542; JUN-04542; JUN 04542; XL092; XL-092; X L092; Zanzalintinib |
| Protocol | In Vivo | Zanzalintinib (10 mg/kg/day; oral; for 14 days) causes substantial tumor growth inhibition in xenograft studies. Zanzalintinib shows 82% and 96% inhibition on p-MET and p-VEGFR2, respectively. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8920 mL | 9.4602 mL | 18.9204 mL | 37.8408 mL |
| 5mM | 0.3784 mL | 1.8920 mL | 3.7841 mL | 7.5682 mL |
| 10mM | 0.1892 mL | 0.9460 mL | 1.8920 mL | 3.7841 mL |
| 20mM | 0.0946 mL | 0.4730 mL | 0.9460 mL | 1.8920 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.