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Size | Price | Stock |
---|---|---|
250mg | $480 | Check With Us |
500mg | $850 | Check With Us |
1g | $1275 | Check With Us |
Cat #: V2683 CAS #: 1223403-58-4 Purity ≥ 98%
Description: Larotrectinib (LOXO-101; LOXO101; ARRY470; ARRY-470; Vitrakvi) is an orally bioactive, highly selective, ATP competitive TRK inhibitor with potential anticancer activity.
References: Karyn Bouhana, et al. LOXO-101, a pan TRK inhibitor, For The Treatment Of TRK-driven Cancers.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
Molecular Weight (MW) | 428.44 |
---|---|
Molecular Formula | C21H22F2N6O2 |
CAS No. | 1223403-58-4 |
Storage | -20℃ for 3 years in powder formr |
-80℃ for 2 years in solvent | |
Solubility In Vitro | DMSO: 100 mg/mL (189.9 mM)r |
Water: <1 mg/mLr | |
Ethanol: 100 mg/mL (189.9 mM) | |
SMILES Code | O=C(N1CC[C@@H](C1)O)NC2=C3N=C(N4CCC[C@@H]4C5=CC(F)=CC=C5F)C=CN3N=C2 |
Synonyms | ARRY-470, Larotrectinib; LOXO 101; LOXO-101; LOXO101; ARRY-470; ARRY470; ARRY 470; trade name: Vitrakvi |
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.3340 mL | 11.6702 mL | 23.3405 mL | 46.6810 mL |
5mM | 0.4668 mL | 2.3340 mL | 4.6681 mL | 9.3362 mL |
10mM | 0.2334 mL | 1.1670 mL | 2.3340 mL | 4.6681 mL |
20mM | 0.1167 mL | 0.5835 mL | 1.1670 mL | 2.3340 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.