ANA-12

This product is for research use only, not for human use. We do not sell to patients.

ANA-12
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$900Check With Us
500mg$1450Check With Us
1g$2175Check With Us

Cat #: V0642 CAS #: 219766-25-3 Purity ≥ 98%

Description: ANA-12 (ANA12) is a novel, potent and selective TrkB inhibitor/antagonist with important biological activity.

References: Cazorla M, et al. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest. 2011 May;121(5):1846-57.

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Product Promise

Promise
Molecular Weight (MW)407.49
Molecular FormulaC22H21N3O3S
CAS No.219766-25-3
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 37 mg/mL (90.79 mM)r
Water: <1 mg/mLrr
Ethanol: <1 mg/mL
SMILES CodeO=C(C1=CC2=CC=CC=C2S1)NC3=CC=CC=C3C(NC4C(NCCCC4)=O)=O
SynonymsANA 12; ANA-12; ANA12;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4540 mL12.2702 mL24.5405 mL49.0810 mL
5mM0.4908 mL2.4540 mL4.9081 mL9.8162 mL
10mM0.2454 mL1.2270 mL2.4540 mL4.9081 mL
20mM0.1227 mL0.6135 mL1.2270 mL2.4540 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.