PF-06273340
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1020 | To Be Confirmed |
| 500mg | $1480 | To Be Confirmed |
| 1g | $2220 | To Be Confirmed |
: Cat #: V2756 CAS #: 1402438-74-7 Purity ≥ 98%
Description: PF-06273340 is a potent, selective, and well-tolerated pan-Trk inhibitor with IC50 of 6, 4, 3 nM for TrkA, TrkB, Trk C respectively.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 479.92 |
|---|---|
| Molecular Formula | C23H22ClN7O3 |
| CAS No. | 1402438-74-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 95 mg/mL (197.94 mM)r |
| Water:<1 mg/mLr | |
| Ethanol:1 mg/mL (2.08 mM) | |
| SMILES Code | NC1=NC=C2C(N(C(C)(C)CO)C=C2C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=N1 |
| Synonyms | PF-06273340; PF 06273340; PF06273340; PF-6273340; PF 6273340; PF6273340. |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0837 mL | 10.4184 mL | 20.8368 mL | 41.6736 mL |
| 5mM | 0.4167 mL | 2.0837 mL | 4.1674 mL | 8.3347 mL |
| 10mM | 0.2084 mL | 1.0418 mL | 2.0837 mL | 4.1674 mL |
| 20mM | 0.1042 mL | 0.5209 mL | 1.0418 mL | 2.0837 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.