PF-4618433

This product is for research use only, not for human use. We do not sell to patients.

PF-4618433
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Size Price Stock
100mg$1950Check With Us
200mg$2925Check With Us
500mg$4935Check With Us

Cat #: V8608 CAS #: 1166393-85-6 Purity ≥ 98%

Description: PF-4618433 is a novel, potent and selective inhibitor of proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK), showing improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796.

References: Seungil H, et, al. Structural Characterization of Proline-Rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design. J Biol Chem. 2009 May 8; 284(19): 13193-201.

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Molecular Weight (MW)445.52
Molecular FormulaC24H27N7O2
CAS No.1166393-85-6
SMILES CodeO=C(NC1=NNC(COC2=CC=CN=C2)=C1)NC3=CC(C(C)(C)C)=NN3C4=CC=C(C)C=C4
SynonymsPF-4618433; PF4618433; PF 4618433;
ProtocolIn VitroPF-4618433 (0.1-1.0 μM; 7 days) promotes osteogenesis of hMSC cultures. PF-4618433 increases in both alkaline phosphatase (ALP) activity and mineralization in a dependent manner.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2446 mL11.2228 mL22.4457 mL44.8914 mL
5mM0.4489 mL2.2446 mL4.4891 mL8.9783 mL
10mM0.2245 mL1.1223 mL2.2446 mL4.4891 mL
20mM0.1122 mL0.5611 mL1.1223 mL2.2446 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.