TAS0728
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1950 | Check With Us |
| 200mg | $2925 | Check With Us |
| 500mg | $4935 | Check With Us |
: Cat #: V15766 CAS #: 2088323-16-2 Purity ≥ 98%
Description: TAS0728 is a potent, selective, covalent, orally bioavailable HER2 inhibitor with IC50 of 36 nM.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 504.58 |
|---|---|
| Molecular Formula | C26H32N8O3 |
| CAS No. | 2088323-16-2 |
| SMILES Code | O=C(C1=NN([C@H]2CN(C(C=C)=O)CCC2)C3=NC=NC(N)=C31)NC4=CC=C(CC(N(C)C)=O)C(C)=C4C |
| Synonyms | TAS0728; TAS-0728; TAS 0728; |
| Protocol | In Vitro | TAS0728 is a covalent-binding inhibitor of HER2 kinase and exhibits high selectivity for HER2 kinase. It also shows inhibitory activity against BMX, HER4, BLK, EGFR, JAK3, SLK, and LOK. |
|---|---|---|
| In Vivo | TAS0728 reveals the sustained and targeted inhibition of phosphorylation of HER2, HER3, AKT and ERK. TAS0728 also shows the ability of tumor regression and low toxicity. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9818 mL | 9.9092 mL | 19.8185 mL | 39.6369 mL |
| 5mM | 0.3964 mL | 1.9818 mL | 3.9637 mL | 7.9274 mL |
| 10mM | 0.1982 mL | 0.9909 mL | 1.9818 mL | 3.9637 mL |
| 20mM | 0.0991 mL | 0.4955 mL | 0.9909 mL | 1.9818 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.