BMS-509744
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2000 | Check With Us |
| 200mg | $3000 | Check With Us |
| 500mg | $5065 | Check With Us |
: Cat #: V3466 CAS #: 439575-02-7 Purity ≥ 98%
Description: BMS-509744 (BMS509744) is a novel, potent and selective inhibitor of interleukin-2 inducible T cell kinase (ITK) with the potential for immunosuppressive and inflammatory diseases.
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| Molecular Weight (MW) | 623.83 |
|---|---|
| Molecular Formula | C32H41N5O4S2 |
| CAS No. | 439575-02-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | Cc1cc(c(cc1Sc2cnc(s2)NC(=O)c3ccc(cc3)CNC(C)C(C)(C)C)C(=O)N4CCN(CC4)C(=O)C)OC |
| Synonyms | BMS-509744; BMS 509744; BMS509744; CHEMBL209148 |
| Protocol | In Vitro | BMS-509744 reduces T-cell receptor-induced functions including PLCγ1 tyrosine phosphorylation, calcium mobilization, IL-2 secretion, and T-cell proliferation in vitro in both human and mouse cells. BMS-488516 and BMS-509744 potently inhibit Itk in vitro with IC50 values of 96 and 19 nM, respectively. Both compounds exhibit competitive kinetics with respect to ATP, suggesting that they bind to the ATP binding site of the Itk kinase domain. |
|---|---|---|
| In Vivo | BMS-509744 and BMS-488516 suppress the production of IL-2 induced by anti-T-cell receptor antibody administered to mice. BMS-509744 exhibits a 50% inhibitory capacity when dosed at 50 mg/kg, irrespective of the amount of induction antibody. BMS-509744 also significantly diminishes lung inflammation in a mouse model of ovalbumin-induced allergy/asthma. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6030 mL | 8.0150 mL | 16.0300 mL | 32.0600 mL |
| 5mM | 0.3206 mL | 1.6030 mL | 3.2060 mL | 6.4120 mL |
| 10mM | 0.1603 mL | 0.8015 mL | 1.6030 mL | 3.2060 mL |
| 20mM | 0.0802 mL | 0.4008 mL | 0.8015 mL | 1.6030 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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