UNC2541
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $950 | To Be Confirmed |
| 250mg | $1550 | To Be Confirmed |
| 500mg | $2325 | To Be Confirmed |
: Cat #: V5200 CAS #: 1612782-86-1 Purity ≥ 98%
Description: UNC2541 is a novel, potent and selective Mer tyrosine kinase (MerTK) inhibitor which binds in the MerTK ATP pocket with an IC50 of 4.4 nM, and it is more selective over Axl, Tyro3 and Flt3.
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| Molecular Weight (MW) | 471.57 |
|---|---|
| Molecular Formula | C24H34FN7O2 |
| CAS No. | 1612782-86-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(NCCCCCCN1)[C@@H](N)CCCCNC2=NC1=NC=C2C(NCC3=CC=C(F)C=C3)=O |
| Synonyms | UNC2541; UNC-2541; UNC 2541; |
| Protocol | In Vitro | UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl (IC50, 120 nM), Tyro3 (IC50, 220 nM) and Flt3 (IC50, 320 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1206 mL | 10.6029 mL | 21.2058 mL | 42.4115 mL |
| 5mM | 0.4241 mL | 2.1206 mL | 4.2412 mL | 8.4823 mL |
| 10mM | 0.2121 mL | 1.0603 mL | 2.1206 mL | 4.2412 mL |
| 20mM | 0.1060 mL | 0.5301 mL | 1.0603 mL | 2.1206 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.