MK-0674
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $4875 | To Be Confirmed |
| 200mg | $7310 | To Be Confirmed |
| 500mg | $12335 | To Be Confirmed |
: Cat #: V4301 CAS #: 887781-62-6 Purity ≥ 98%
Description: MK-0674 is a novel, potent, orally bioavailable and selective cathepsin K inhibitor with an IC50 of 0.4 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 527.50 |
|---|---|
| Molecular Formula | C26H27F6N3O2 |
| CAS No. | 887781-62-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Synonyms | MK-0674 |
| Protocol | In Vitro | MK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8957 mL | 9.4787 mL | 18.9573 mL | 37.9147 mL |
| 5mM | 0.3791 mL | 1.8957 mL | 3.7915 mL | 7.5829 mL |
| 10mM | 0.1896 mL | 0.9479 mL | 1.8957 mL | 3.7915 mL |
| 20mM | 0.0948 mL | 0.4739 mL | 0.9479 mL | 1.8957 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.