TCS JNK 5a
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1050 | Check With Us |
| 1g | $1750 | Check With Us |
| 5g | $4425 | Check With Us |
: Cat #: V0473 CAS #: 312917-14-9 Purity ≥ 98%
Description: TCS JNK 5a (also known as JNK Inhibitor IX; TCS JNK-5a) is a novel, highly selective and potent JNK (c-Jun N-terminal Kinase) inhibitor with potential antineoplastic activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 332.42 |
|---|---|
| Molecular Formula | C20H16N2OS |
| CAS No. | 312917-14-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO:20 mg/mL (60.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| SMILES Code | O=C(C1=CC=CC2=CC=CC=C21)NC(S3)=C(C#N)C4=C3CCCC4 |
| Synonyms | SC202671, JNK Inhibitor-IX, TCS-JNK-5a, TCS JNK 5a, JNK Inhibitor IX, SC-202671, SC 202671, |
| Protocol | In Vitro | TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0082 mL | 15.0412 mL | 30.0824 mL | 60.1649 mL |
| 5mM | 0.6016 mL | 3.0082 mL | 6.0165 mL | 12.0330 mL |
| 10mM | 0.3008 mL | 1.5041 mL | 3.0082 mL | 6.0165 mL |
| 20mM | 0.1504 mL | 0.7521 mL | 1.5041 mL | 3.0082 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.