KB-R7943 mesylate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $450 | To Be Confirmed |
| 250mg | $700 | To Be Confirmed |
| 500mg | $1050 | To Be Confirmed |
: Cat #: V9844 CAS #: 182004-65-5 Purity ≥ 99%
Description: KB-R7943 mesylate, the mesylate salt of KB-R-7943, is a novel and potent reverse Na(+) /Ca(2+) exchanger (NCX(rev)) with neuroprotective action.
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| Molecular Weight (MW) | 427.50 |
|---|---|
| Molecular Formula | C17H21N3O6S2 |
| CAS No. | 182004-65-5 |
| SMILES Code | N=C(N)SCCC1=CC=C(OCC2=CC=C([N+]([O-])=O)C=C2)C=C1.OS(=O)(C)=O |
| Synonyms | KB-R7943; KB R7943; KB-R 7943; KB-R7943 mesylate |
| Protocol | In Vitro | KB-R7943 mesylate blocks NMDAR-mediated ion currents, and inhibits NMDA-induced increase in cytosolic Ca2+ with IC50=13.4±3.6 µM but accelerates calcium deregulation and mitochondrial depolarization in glutamate-treated neurons. KB-R7943 depolarizes mitochondria in a Ca2+-independent manner. KB-R7943 inhibits 2,4-dinitrophenol-stimulated respiration of cultured neurons with IC50=11.4±2.4 µM. In addition to NCXrev, KB-R7943 dose-dependently and reversibly blocked ion currents elicited by NMDA. KB-R7943 dose-dependently inhibits NMDA-induced increases in [Ca2+]c with IC50=13.4±3.6 µM confirming the inhibition of NMDA receptors observed in electrophysiological experiments. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3392 mL | 11.6959 mL | 23.3918 mL | 46.7836 mL |
| 5mM | 0.4678 mL | 2.3392 mL | 4.6784 mL | 9.3567 mL |
| 10mM | 0.2339 mL | 1.1696 mL | 2.3392 mL | 4.6784 mL |
| 20mM | 0.1170 mL | 0.5848 mL | 1.1696 mL | 2.3392 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
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