JNK-IN-8
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1050 | Check With Us |
| 500mg | $1650 | Check With Us |
| 1g | $2475 | Check With Us |
: Cat #: V0472 CAS #: 1410880-22-6 Purity ≥ 98%
Description: JNK-IN-8 (JNK Inhibitor XVI; JNK-IN8) is the first irreversible/covalent inhibitor of pan-JNK (c-Jun N-terminal Kinase) with potential antitumor activity.
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| Molecular Weight (MW) | 507.59 |
|---|---|
| Molecular Formula | C29H29N7O2 |
| CAS No. | 1410880-22-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (197.0 mM)r |
| Water: <1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 10mg/mL |
| SMILES Code | CN(C/C=C/C(NC1=CC=CC(C(NC2=CC=C(C(C)=C2)NC3=NC=CC(C4=CN=CC=C4)=N3)=O)=C1)=O)C |
| Synonyms | Synonym: JNK Inhibitor XVI; JNK-IN 8; JNK-IN8; JNK-IN 8; c-Jun N-terminal Kinase Inhibitor XVI. |
| Protocol | In Vitro | JNK-IN-8 (GMP) (2 μM, 7 days) enhances the self-renewal of human hematopoietic stem cells (HSCs) through the downregulation of C-JUN phosphorylation. JNK-IN-8 (GMP) (10 μM) reduces WNT3A-mediated neuronal differentiation. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9701 mL | 9.8505 mL | 19.7009 mL | 39.4019 mL |
| 5mM | 0.3940 mL | 1.9701 mL | 3.9402 mL | 7.8804 mL |
| 10mM | 0.1970 mL | 0.9850 mL | 1.9701 mL | 3.9402 mL |
| 20mM | 0.0985 mL | 0.4925 mL | 0.9850 mL | 1.9701 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.