LUT-014

This product is for research use only, not for human use. We do not sell to patients.

LUT-014
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1650Check With Us
250mg$2650Check With Us
500mg$3975Check With Us

Cat #: V4222 CAS #: 2274819-46-2 Purity ≥ 98%

Description: LUT014 is a novel, potent and topical B-Raf Inhibitor which is a proprietary, first-in-class, small molecule allowing administration of EGFR (Epidermal Growth Factor Receptor) Inhibitors to patients without interruptions caused by typical cutaneous side effects.

References: Noa Shelach. Novel braf inhibitors and use there of for treatment of cutaneous reactions. WO2019026065A2.

Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products

Product Promise

Promise
Molecular Weight (MW)528.49
Molecular FormulaC27H19F3N8O
CAS No.2274819-46-2
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeFC(F)(F)OC1=CC(NC2=NC=CC3=C2C=CC(C)=C3NC4=NC=CC=C4C5=C6C(NC=N6)=NC=N5)=CC=C1
SynonymsLUT-014; LUT 014; LUT014;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.8922 mL9.4609 mL18.9218 mL37.8437 mL
5mM0.3784 mL1.8922 mL3.7844 mL7.5687 mL
10mM0.1892 mL0.9461 mL1.8922 mL3.7844 mL
20mM0.0946 mL0.4730 mL0.9461 mL1.8922 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.