Dabrafenib mesylate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $249 | Check With Us |
| 1g | $390 | Check With Us |
| 5g | $987 | Check With Us |
: Cat #: V3634 CAS #: 1195768-06-9 Purity ≥ 98%
Description: Dabrafenib mesylate (formerly GSK-2118436 mesylate; Tafinlar), the mesylate salt of dabrafenib, is an orally bioavailable BRAF V600 inhibitor that has been approved in 2013 by FDA to treat melanoma.
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| Molecular Weight (MW) | 615.66 |
|---|---|
| Molecular Formula | C24H24F3N5O5S3 |
| CAS No. | 1195768-06-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >30 mg/mL (57.74 mM)r |
| Water: N/Ar | |
| Ethanol: N/A | |
| Solubility In Vivo | 30% PEG400+0.5% Tween80+5% Propylene glycol: 8 mg/mL |
| SMILES Code | O=S(C1=C(F)C=CC=C1F)(NC2=CC=CC(C3=C(C4=NC(N)=NC=C4)SC(C(C)(C)C)=N3)=C2F)=O.CS(=O)(O)=O |
| Synonyms | GSK2118436A Mesylate; GSK 2118436A Mesylate; GSK-2118436A; GSK2118436B ( Dabrafenib Mesylate); GSK-2118436B Mesylate; GSK 2118436B. Trade name: Tafinlar. |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6243 mL | 8.1214 mL | 16.2427 mL | 32.4855 mL |
| 5mM | 0.3249 mL | 1.6243 mL | 3.2485 mL | 6.4971 mL |
| 10mM | 0.1624 mL | 0.8121 mL | 1.6243 mL | 3.2485 mL |
| 20mM | 0.0812 mL | 0.4061 mL | 0.8121 mL | 1.6243 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.