NVP-BHG712 (BHG712)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $800 | Check With Us |
| 500mg | $2550 | Check With Us |
| 1g | $3825 | Check With Us |
: Cat #: V1007 CAS #: 940310-85-0 Purity ≥ 98%
Description: NVP-BHG712 (NVP BHG-712; NVP BHG712; BHG-712) is a selective and orally bioavailable EphB4 inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 503.48 |
|---|---|
| Molecular Formula | C26H20F3N7O |
| CAS No. | 940310-85-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 101 mg/mL (200.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 3 mg/mL (5.95 mM) | |
| Solubility In Vivo | NMP+polyethylene glycol 300 (10/90, v/v): 30mg/mL |
| SMILES Code | O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(NC3=C4C(N(C)N=C4)=NC(C5=CC=CN=C5)=N3)=C2 |
| Synonyms | NVP-BHG712; NVP BHG-712; NVP BHG712; NVP BHG712; NVP BHG-712; NVP BHG 712 |
| Protocol | In Vitro | NVP-BHG712 inhibits VEGF driven vessel formation, while it has only little effects on VEGF receptor (VEGFR) activity. The data suggests a close cross talk between the VEGFR and EphR signaling during vessel formation. |
|---|---|---|
| In Vivo | NVP-BHG712 (3, 10 and 30 mg/kg, p.o., daily) inhibits VEGF driven tissue growth and angiogenesis. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9862 mL | 9.9309 mL | 19.8618 mL | 39.7235 mL |
| 5mM | 0.3972 mL | 1.9862 mL | 3.9724 mL | 7.9447 mL |
| 10mM | 0.1986 mL | 0.9931 mL | 1.9862 mL | 3.9724 mL |
| 20mM | 0.0993 mL | 0.4965 mL | 0.9931 mL | 1.9862 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.