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Rineterkib (LTT-462; ERK-IN-1)

This product is for research use only, not for human use. We do not sell to patients.

Rineterkib (LTT-462; ERK-IN-1)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$2025Check With Us
200mg$3035Check With Us
500mg$5120Check With Us
email: [email protected]        [email protected]

Cat #: V4794 CAS #: 1715025-32-3 Purity ≥ 98%

Description: Rineterkib (LTT-462; ERK-IN-1; ERK-IN1), the compound B extracted from WO2018051306A1, is a novel and potent RAF and ERK1/2 inhibitor with anticancer activity.

References: CAPONIGRO, et al. THERAPEUTIC COMBINATIONS COMPRISING A RAF INHIBITOR AND A ERK INHIBITOR. WO2018051306A1.

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Molecular Weight (MW)578.42
Molecular FormulaC₂₆H₂₇BrF₃N₅O₂
CAS No.1715025-32-3
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeO=C(N[C@@H](C1=CC(F)=CC(Br)=C1)CNC)C2=CC=C(C3=NC([C@@H]4C[C@H](F)[C@@H](O)CC4)=CN=C3N)C=C2F
SynonymsLTT 462; LTT-462; LTT462; Rineterkib; ERK-IN-1; ERK IN 1; ERK IN-1; ERK-IN 1;
ProtocolIn VivoRineterkib (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.7288 mL8.6442 mL17.2885 mL34.5770 mL
5mM0.3458 mL1.7288 mL3.4577 mL6.9154 mL
10mM0.1729 mL0.8644 mL1.7288 mL3.4577 mL
20mM0.0864 mL0.4322 mL0.8644 mL1.7288 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.