VX-11e
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1150 | Check With Us |
| 500mg | $1850 | Check With Us |
| 1g | $2775 | Check With Us |
: Cat #: V0468 CAS #: 896720-20-0 Purity ≥ 98%
Description: VX-11e is a novel, potent, selective, and orally bioavailable ERK2 (extracellular signal-related kinase 2) inhibitor with potential anticancer activity.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 500.35 |
|---|---|
| Molecular Formula | C24H20Cl2FN5O2 |
| CAS No. | 896720-20-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (199.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 16 mg/mL (32.0 mM) | |
| SMILES Code | O=C(C1=CC(C2=NC(NC3=CC=C(F)C=C3Cl)=NC=C2C)=CN1)N[C@@H](C4=CC=CC(Cl)=C4)CO |
| Synonyms | TCS ERK 11e; TCS ERK-11e; TCS ERK11e; ERK-11e; ERK 11e; ERK11e; VTX-11e, Vertex-11e; VX-11e; VX 11e; VX11e; VTX-11e; VTX11e; VTX 11e |
| Protocol | In Vitro | VX-11e is active in the HT29 cell proliferation assay (IC50=48 nM). |
|---|---|---|
| In Vivo | VX-11e is orally bioavailable in both rat and mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9986 mL | 9.9930 mL | 19.9860 mL | 39.9720 mL |
| 5mM | 0.3997 mL | 1.9986 mL | 3.9972 mL | 7.9944 mL |
| 10mM | 0.1999 mL | 0.9993 mL | 1.9986 mL | 3.9972 mL |
| 20mM | 0.0999 mL | 0.4997 mL | 0.9993 mL | 1.9986 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.