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Honokiol (NSC-293100)

This product is for research use only, not for human use. We do not sell to patients.

Honokiol (NSC-293100)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$290Check With Us
2g$520Check With Us
5g$875Check With Us

Cat #: V0167 CAS #: 35354-74-6 Purity ≥ 98%

Description: Honokiol (also known as NSC 293100) is a naturally-occuring, bioactive, biphenolic phytochemical and an active ingredient of magnolia extract with potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities.

References: Chang KH, et al. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013 Nov;6(5):1435-1438.

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Molecular Weight (MW)266.334
Molecular FormulaC18H18O2
CAS No.35354-74-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 53 mg/mL (198.99 mM)r
Water: <1 mg/mLr
Ethanol: <1 mg/mL
SMILES CodeOC1=CC=C(CC=C)C=C1C2=CC=C(O)C(CC=C)=C2
SynonymsHonokiol, Houpa; Hnk
ProtocolIn VitroHonokiol (0, 12.5, 25 and 50 μM) inhibits the growth of GBM cells and induces apoptosis, with IC50 of appr against 30 μM DBTRG-05MG cell. Honokiol-induced apoptosis of GBM cells is associated with the downregulation of the Rb protein and cleavage of PARP and Bcl-x (S/L). Honokiol (50 μM) increases the level of autophagy markers in GBM cells.
In VivoHonokiol-NM (40 mg/kg, p.o.) produces superior anticancer effects, and the PCNA, Cyclin D1 and cleaved caspase 3 expressions are 2.12, 1.92 and 1.68-fold significantly altered in this treated group.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.7547 mL18.7734 mL37.5468 mL75.0937 mL
5mM0.7509 mL3.7547 mL7.5094 mL15.0187 mL
10mM0.3755 mL1.8773 mL3.7547 mL7.5094 mL
20mM0.1877 mL0.9387 mL1.8773 mL3.7547 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.