Cobimetinib racemate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1450 | Check With Us |
| 500mg | $2080 | Check With Us |
| 1g | $3120 | Check With Us |
: Cat #: V4523 CAS #: 934662-91-6 Purity ≥ 98%
Description: Cobimetinib racemate is the racemic mixture of Cobimetinib (GDC-0973, RG7420; XL-518; Cotellic), which is a novel, orally bioavailable, highly potent and selective small-molecule MEK1 inhibitor with antitumor activity.
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| Molecular Weight (MW) | 531.31 |
|---|---|
| Molecular Formula | C21H21F3IN3O2 |
| CAS No. | 934662-91-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (188.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 47 mg/mL (88.46 mM) | |
| Solubility In Vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O: 5 mg/mL |
| Synonyms | XL518 racemate, GDC-0973, RG7420 racemate; XL518; RG-7420; XL 518; GDC-0973; XL-518 racemate; GDC0973 racemate; GDC 0973; RG 7420 racemate |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8821 mL | 9.4107 mL | 18.8214 mL | 37.6428 mL |
| 5mM | 0.3764 mL | 1.8821 mL | 3.7643 mL | 7.5286 mL |
| 10mM | 0.1882 mL | 0.9411 mL | 1.8821 mL | 3.7643 mL |
| 20mM | 0.0941 mL | 0.4705 mL | 0.9411 mL | 1.8821 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.