PF-06726304
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1300 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2925 | Check With Us |
: Cat #: V4563 CAS #: 1616287-82-1 Purity ≥ 98%
Description: PF-06726304 is a novel, potent and selective SAM-competitive EZH2 (enhancer of zeste homolog 2) inhibitor with a Ki of 0.7 nM.
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| Molecular Weight (MW) | 446.33 |
|---|---|
| Molecular Formula | C22H21Cl2N3O3 |
| CAS No. | 1616287-82-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C1N(CC2=C(C)C=C(C)NC2=O)CCC3=C1C(Cl)=C(C4=C(C)ON=C4C)C=C3Cl |
| Synonyms | PF-06726304; PF 06726304; PF06726304; PF-6726304; PF 6726304; PF672630 |
| Protocol | In Vitro | PF-06726304 inhibits the proliferation of Karpas-422 cells that harbor wild-type EZH2 with an IC50 of 25 nM. PF-06726304 (Compound 31) inhibits H3K27me3 in Karpas-422 with an IC50 of 15 nM. |
|---|---|---|
| In Vivo | PF-06726304 (200 and 300 mg/kg; BID for 20 days) inhibits tumor growth and induces robust modulation of downstream biomarkers in a subcutaneous Karpas-422 xenograft model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2405 mL | 11.2025 mL | 22.4049 mL | 44.8099 mL |
| 5mM | 0.4481 mL | 2.2405 mL | 4.4810 mL | 8.9620 mL |
| 10mM | 0.2240 mL | 1.1202 mL | 2.2405 mL | 4.4810 mL |
| 20mM | 0.1120 mL | 0.5601 mL | 1.1202 mL | 2.2405 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
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%ddH2O
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Method for preparing DMSO master liquid:
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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