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LIN28 inhibitor LI71

This product is for research use only, not for human use. We do not sell to patients.

LIN28 inhibitor LI71
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$2600To Be Confirmed
200mg$3900To Be Confirmed
500mg$6580To Be Confirmed

Cat #: V33118 CAS #: 1357248-83-9 Purity ≥ 99%

Description: LIN28 inhibitor LI71 is a potent ,novel and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM.

References: Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101.

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Promise
Molecular Weight (MW)335.40
Molecular FormulaC21H21NO3
CAS No.1357248-83-9
SMILES CodeO=C(O)C1=CC=C([C@@H]2NC3=C(C=CC=C3OCC)[C@@]4([H])[C@]2([H])CC=C4)C=C1
SynonymsLIN28 inhibitor LI71; L-I71; L I71; IUPAC/Chemical Name: 4-((3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetra
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.9815 mL14.9076 mL29.8151 mL59.6303 mL
5mM0.5963 mL2.9815 mL5.9630 mL11.9261 mL
10mM0.2982 mL1.4908 mL2.9815 mL5.9630 mL
20mM0.1491 mL0.7454 mL1.4908 mL2.9815 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.