AZ505 free base
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1550 | Check With Us |
| 200mg | $2325 | Check With Us |
| 500mg | $3920 | Check With Us |
: Cat #: V12012 CAS #: 1035227-43-0 Purity ≥ 98%
Description: AZ505 (AZ-505) is a novel, potent and highly selective inhibitor of SMYD2 (IC50 120 nM) with antitumor activity.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 577.54 |
|---|---|
| Molecular Formula | C29H38Cl2N4O4 |
| CAS No. | 1035227-43-0 |
| SMILES Code | O=C(CCNCCC1=CC=C(C(Cl)=C1)Cl)N(CCNCCC2=C(OC3)C(NC3=O)=C(C=C2)O)C4CCCCC4 |
| Synonyms | AZ505 free base; AZ505; AZ-505; AZ 505; |
| Protocol | In Vitro | AZ505 is highly selective and shows an activity at submicromolar concentrations in vitro. The IC50 of AZ505 for SMYD2 is 0.12 μM, which is >600-fold greater than the IC50s of AZ505 for other histone methyltransferases, such as SMYD3 (IC50>83.3 μM), DOT1L (IC50>83.3 μM) and EZH2 (IC50>83.3 μM). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7315 mL | 8.6574 mL | 17.3148 mL | 34.6296 mL |
| 5mM | 0.3463 mL | 1.7315 mL | 3.4630 mL | 6.9259 mL |
| 10mM | 0.1731 mL | 0.8657 mL | 1.7315 mL | 3.4630 mL |
| 20mM | 0.0866 mL | 0.4329 mL | 0.8657 mL | 1.7315 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.