D-erythro-Sphingosine (Erythrosphingosine)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $520 | Check With Us |
| 1g | $850 | Check With Us |
| 5g | $2150 | Check With Us |
: Cat #: V33467 CAS #: 123-78-4 Purity ≥ 99%
Description: D-erythro-Sphingosine (Erythrosphingosine) is a highly potent activator of p32-kinase with an EC50 of 8 μM.
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- Related Biological Data
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| Molecular Weight (MW) | 299.49 |
|---|---|
| Molecular Formula | C18H37NO2 |
| CAS No. | 123-78-4 |
| SMILES Code | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO |
| Synonyms | D-erythro-Sphingosine; Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine |
| Protocol | In Vitro | A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.3390 mL | 16.6950 mL | 33.3901 mL | 66.7802 mL |
| 5mM | 0.6678 mL | 3.3390 mL | 6.6780 mL | 13.3560 mL |
| 10mM | 0.3339 mL | 1.6695 mL | 3.3390 mL | 6.6780 mL |
| 20mM | 0.1670 mL | 0.8348 mL | 1.6695 mL | 3.3390 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.