Apostatin-1 (Apt-1)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $650 | To Be Confirmed |
| 250mg | $1200 | To Be Confirmed |
| 500mg | $1800 | To Be Confirmed |
: Cat #: V41787 CAS #: 2559703-06-7 Purity ≥ 99%
Description: Apostatin-1 (Apt-1) is a novel and potent TRADD inhibitor.
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| Molecular Weight (MW) | 345.50 |
|---|---|
| Molecular Formula | C19H27N3OS |
| CAS No. | 2559703-06-7 |
| Synonyms | Apostatin-1; Apt-1 |
| Protocol | In Vitro | Apostatin-1 (10 μM, 6 h) effectively induces autophagy and the degradation of long-lived proteins. Apostatin-1 inhibits Velcade (Bortezomib, HY-134050)-induced apoptosis and RIPK1-dependent apoptosis (RDA) and necroptosis, with an IC50 of 0.97 μM. |
|---|---|---|
| In Vivo | Apostatin-1 (20 mg/kg, IP, once) inhibits inflammatory responses, and increases survival of systemic inflammation mouse model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8944 mL | 14.4718 mL | 28.9436 mL | 57.8871 mL |
| 5mM | 0.5789 mL | 2.8944 mL | 5.7887 mL | 11.5774 mL |
| 10mM | 0.2894 mL | 1.4472 mL | 2.8944 mL | 5.7887 mL |
| 20mM | 0.1447 mL | 0.7236 mL | 1.4472 mL | 2.8944 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.