Alogliptin (SYR322)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $350 | Check With Us |
| 5g | $650 | Check With Us |
| 10g | $975 | Check With Us |
: Cat #: V0745 CAS #: 850649-61-5 Purity ≥ 98%
Description: Alogliptin (formerly also known as SYR-322; trade names Nesina; Kazano, Oseni) is a novel, potent, orally bioavailable, and selective inhibitor of DPP-4 (serine protease dipeptidyl peptidase IV) with potential anti-hyperglycemic activity.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 339.39 |
|---|---|
| Molecular Formula | C18H21N5O2 |
| CAS No. | 850649-61-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 68 mg/mL (200.4 mM)r |
| Water: 2 mg/mL (5.89 mM)r | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | 0.5% methylcellulose: 30 mg/mL |
| SMILES Code | n1(c(=O)cc(n(c1=O)Cc1c(cccc1)C#N)N1C[C@@H](CCC1)N)C |
| Synonyms | SYR 322; Alogliptin; SYR-322; SYR322; Brand name: Nesina, Kazano, Oseni |
| Protocol | In Vitro | Alogliptin (1 nM; 5-60 min) inhibits LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation in U937 cells. |
|---|---|---|
| In Vivo | Alogliptin (0.01-1 mg/kg; p.o.) produced dose-dependent improvements in glucose tolerance and increased plasma insulin levels in female Wistar fatty rats. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9465 mL | 14.7323 mL | 29.4646 mL | 58.9293 mL |
| 5mM | 0.5893 mL | 2.9465 mL | 5.8929 mL | 11.7859 mL |
| 10mM | 0.2946 mL | 1.4732 mL | 2.9465 mL | 5.8929 mL |
| 20mM | 0.1473 mL | 0.7366 mL | 1.4732 mL | 2.9465 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.