T-26c
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | Check With Us |
| 1g | $1950 | Check With Us |
| 5g | $4935 | Check With Us |
: Cat #: V4258 CAS #: 869296-13-9 Purity ≥ 98%
Description: T-26c is a novel, highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with an IC50 of 6.75 pM and shows more than 2600-fold selectivity over the other related metalloenzymes.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 479.51 |
|---|---|
| Molecular Formula | C₂₄H₂₁N₃O₆S |
| CAS No. | 869296-13-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(O)C1=CC=C(COCC2=CSC(N=C(C(NCC3=CC=CC(OC)=C3)=O)N4)=C2C4=O)C=C1 |
| Synonyms | T-26c, T26c, T 26c |
| Protocol | In Vitro | T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage. |
|---|---|---|
| In Vivo | T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0855 mL | 10.4273 mL | 20.8546 mL | 41.7092 mL |
| 5mM | 0.4171 mL | 2.0855 mL | 4.1709 mL | 8.3418 mL |
| 10mM | 0.2085 mL | 1.0427 mL | 2.0855 mL | 4.1709 mL |
| 20mM | 0.1043 mL | 0.5214 mL | 1.0427 mL | 2.0855 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.