RO4929097 (RO4929097; R4733; RO04929097)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $750 | In Stock |
| 250mg | $1250 | In Stock |
| 500mg | $1875 | In Stock |
: Cat #: V0715 CAS #: 847925-91-1 Purity ≥ 98%
Description: RO4929097 (also called RO-4929097; RO04929097; R-4733) is a novel, potent and orally bioavailable small molecule inhibitor of the γ-secretase (gamma secretase-GS) with potential antitumor activity.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 469.4 |
|---|---|
| Molecular Formula | C22H20F5N3O3 |
| CAS No. | 847925-91-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 94 mg/mL (200.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 16 mg/mL (34.1 mM) | |
| Solubility In Vivo | 2% DMSO+30% PEG 300+5% Tween+ddH2O: 10 mg/mL |
| SMILES Code | O=C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O)C(C)(C)C(NCC(F)(F)C(F)(F)F)=O |
| Synonyms | RO4929097; RO-4929097; RO 4929097; RO04929097; RO-04929097; RO 04929097; R4733; R 4733; R-4733; |
| Protocol | In Vitro | RO4929097 inhibits the production of ICN reducing the expression of the downstream Notch target, Hes1, producing a less transformed morphology in A549 cells. RO4929097 inhibits Notch processing in human tumor-derived cells. |
|---|---|---|
| In Vivo | RO4929097 (3-60 mg/kg, p.o.) results in significant tumor growth inhibition in nude mice bearing A549 NSCLC xenografts, compared with vehicle-treated animals. When mice are treated with 60 mg/kg RO4929097 twice daily with the 7+/14- schedule, treatment initially causes regression of established A549 tumors. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1304 mL | 10.6519 mL | 21.3038 mL | 42.6076 mL |
| 5mM | 0.4261 mL | 2.1304 mL | 4.2608 mL | 8.5215 mL |
| 10mM | 0.2130 mL | 1.0652 mL | 2.1304 mL | 4.2608 mL |
| 20mM | 0.1065 mL | 0.5326 mL | 1.0652 mL | 2.1304 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.