KG-501
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $380 | Check With Us |
| 500mg | $550 | Check With Us |
| 1g | $825 | Check With Us |
: Cat #: V3685 CAS #: 18228-17-6 Purity ≥ 98%
Description: KG-501 is a potent inhibitor of CREB (cAMP response element-binding protein) with an IC50 of 6.89 μM.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 377.71 |
|---|---|
| Molecular Formula | C17H13ClNO5P |
| CAS No. | 18228-17-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water:r | |
| Ethanol: | |
| SMILES Code | O=C(C1=C(OP(O)(O)=O)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3 |
| Synonyms | KG-501; KG 501; KG501 |
| Protocol | In Vitro | KG-501, which directly targets the KIX domain of CBP, results in a disrupted CREB-CBP complex, inhibits CREB-target gene induction, and inhibits IL-1β-mediated angiogenic activity in NSCLC. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6475 mL | 13.2377 mL | 26.4753 mL | 52.9507 mL |
| 5mM | 0.5295 mL | 2.6475 mL | 5.2951 mL | 10.5901 mL |
| 10mM | 0.2648 mL | 1.3238 mL | 2.6475 mL | 5.2951 mL |
| 20mM | 0.1324 mL | 0.6619 mL | 1.3238 mL | 2.6475 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.