MI-136
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $220 | Check With Us |
| 1g | $350 | Check With Us |
| 5g | $885 | Check With Us |
: Cat #: V32467 CAS #: 1628316-74-4 Purity ≥ 99%
Description: MI-136 inhibits DHT-induced expression of androgen receptor (AR) target genes.
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| Molecular Weight (MW) | 470.51 |
|---|---|
| Molecular Formula | C23H21F3N6S |
| CAS No. | 1628316-74-4 |
| SMILES Code | FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=CC=C(NC(C#N)=C5)C5=C4)CC3 |
| Synonyms | MI-136; MI136; MI 136 |
| Protocol | In Vitro | MI-136 (0-20) exhibits IC50values of 5.59 μM, 7.15 μM, 5.37 μM and 19.76 μM in LNCaP, VCaP, 22rv1 and PNT2 cells. |
|---|---|---|
| In Vivo | MI-136 exhibits T1/2 of 3.1 h after po administration. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1254 mL | 10.6268 mL | 21.2535 mL | 42.5071 mL |
| 5mM | 0.4251 mL | 2.1254 mL | 4.2507 mL | 8.5014 mL |
| 10mM | 0.2125 mL | 1.0627 mL | 2.1254 mL | 4.2507 mL |
| 20mM | 0.1063 mL | 0.5313 mL | 1.0627 mL | 2.1254 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.