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Menin-MLL inhibitor 20

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Menin-MLL inhibitor 20
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Cat #: V2515 CAS #: 2448173-47-3 Purity ≥ 99%

Description: Menin-MLL inhibitor 20, is a novel and irreversible menin-MLL interaction inhibitor with antitumor activities.

References: Thomas Butler, et al. Irreversible inhibitors of menin-mll interaction. WO2020142557A1.

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Molecular Weight (MW)612.72
Molecular FormulaC33H40N8O4
CAS No.2448173-47-3
SMILES CodeO=C(OC(C)(C)C)N[C@H]1CN(CC2=CC(C(NC3=CC=C(C4=CC5=C(N6CCOCC6)N=CN=C5N4)C=C3)=O)=NC=C2)CCC1
SynonymsMenin-MLL inhibitor 20; MRN-73473; MRN 73473; MRN73473;
ProtocolIn VitroThe Histone-lysine N-methyltransferase 2 (KMT2) family of proteins, which currently consists of at least 5 members, methylate ly sine 4 on the histone H3 tails at important regulatory regions in the genome and thereby impart crucial functions through the modulation of chromatin structures and DNA accessibility. These enzymes are known to play an important role in the regulation of gene expression during early development and hematopoiesis. The human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member in this disease.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.6321 mL8.1603 mL16.3207 mL32.6413 mL
5mM0.3264 mL1.6321 mL3.2641 mL6.5283 mL
10mM0.1632 mL0.8160 mL1.6321 mL3.2641 mL
20mM0.0816 mL0.4080 mL0.8160 mL1.6321 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.