ZL0420

This product is for research use only, not for human use. We do not sell to patients.

ZL0420
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1020Check With Us
500mg$1480Check With Us
1g$2220Check With Us

Cat #: V3857 CAS #: 2229039-45-4 Purity ≥ 98%

Description: ZL0420 (ZL-0420), an analog of ZL0454, is a novel potent and highly selective inhibitor of BRD4 (Bromodomain-Containing Protein 4) with anti-inflammatory activity.

References: Zhiqing Liu, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461.

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Product Promise

Promise
Molecular Weight (MW)296.33
Molecular FormulaC16H16N4O2
CAS No.2229039-45-4
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10 mMr
Water: N/Ar
Ethanol: N/A
SMILES CodeCC1=C(O)C=C(N)C(/N=N/C2=CC(CCC(N3)=O)=C3C=C2)=C1
SynonymsZL0420; ZL 0420; ZL-0420
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.3746 mL16.8731 mL33.7462 mL67.4923 mL
5mM0.6749 mL3.3746 mL6.7492 mL13.4985 mL
10mM0.3375 mL1.6873 mL3.3746 mL6.7492 mL
20mM0.1687 mL0.8437 mL1.6873 mL3.3746 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.