BRM/BRG1 ATP Inhibitor-1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2800 | Check With Us |
| 200mg | $4200 | Check With Us |
| 500mg | $7085 | Check With Us |
: Cat #: V2478 CAS #: 2270879-17-7 Purity ≥ 99%
Description: BRM/BRG1 ATP Inhibitor-1 is an orally bioactive inhibitor of Brahma Homolog (BRM)/SMARCA2 ATPase with anticancer activity and has potential to be used for the treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
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| Molecular Weight (MW) | 318.27 |
|---|---|
| Molecular Formula | C11H9F3N4O2S |
| CAS No. | 2270879-17-7 |
| SMILES Code | O=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2 |
| Synonyms | NVP-RXI570; NVP-RXI-570; NVP-RXI 570; BRM/BRG1 ATP Inhibitor-1; CUN79177; CUN79177; CUN-79177; |
| Protocol | In Vitro | BRM/BRG1 ATP Inhibitor-1 inhibits KRT80 gene expression in H1299 cells with the AAC50 (absolute AC50) value of 0.01 μM and in RERF-LC-AI cells with an AAC50 value of 0.01 μM. BRM/BRG1 ATP Inhibitor-1 (compound 14) (0-10 μM, 5 days) can inhibit the proliferation of cancer cells. |
|---|---|---|
| In Vivo | BRM/BRG1 ATP Inhibitor-1 (compound 14) (oral administration, 7.5 or 20 mg/kg, everyday, 3 weeks) can inhibit tumor growth and inhibit KRT80 expression in a dose-dependent manner. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1420 mL | 15.7099 mL | 31.4199 mL | 62.8397 mL |
| 5mM | 0.6284 mL | 3.1420 mL | 6.2840 mL | 12.5679 mL |
| 10mM | 0.3142 mL | 1.5710 mL | 3.1420 mL | 6.2840 mL |
| 20mM | 0.1571 mL | 0.7855 mL | 1.5710 mL | 3.1420 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.