GSK6853 | CAS 1910124-24-1

GSK6853

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1020	Check With Us
500mg	$1480	Check With Us
1g	$2220	Check With Us

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Cat #: V2764 CAS #: 1910124-24-1 Purity ≥ 98%

Description: GSK6853 is a novel, potent and selective benzimidazolone BRPF1 bromodomain inhibitor with pIC50 of 8.1 (TR-FRET) and showed greater than 1600-fold selectivity over all other bromodomains tested.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	409.48
Molecular Formula	C22H27N5O3
CAS No.	1910124-24-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 81 mg/mL warmed (197.81 mM)r
	Water: <1 mg/mLr
	Ethanol: 81 mg/mL warmed (197.81 mM)
SMILES Code	O=C(NC1=C(N2[C@H](C)CNCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
Synonyms	GSK6853; GSK 6853; GSK-6853

Protocol	In Vivo	The ip route of administration would be suitable for dosing GSK6853 in potential PK/PD models.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4421 mL	12.2106 mL	24.4212 mL	48.8424 mL
5mM	0.4884 mL	2.4421 mL	4.8842 mL	9.7685 mL
10mM	0.2442 mL	1.2211 mL	2.4421 mL	4.8842 mL
20mM	0.1221 mL	0.6105 mL	1.2211 mL	2.4421 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.