Lomeguatrib (PaTrin2)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $580 | Check With Us |
| 500mg | $1050 | Check With Us |
| 1g | $1575 | Check With Us |
: Cat #: V0409 CAS #: 192441-08-0 Purity ≥ 98%
Description: Lomeguatrib (formerly PaTrin-2) is a novel, potent and selective inhibitor of MGMT (O6-alkylguanine-DNA-alkyltransferase) with anticancer activity.
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| Molecular Weight (MW) | 326.17 |
|---|---|
| Molecular Formula | C10H8BrN5OS |
| CAS No. | 192441-08-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 65 mg/mL (199.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| SMILES Code | BrC1=CSC(COC2=C3N=CNC3=NC(N)=N2)=C1 |
| Synonyms | PaTrin-2; Lomeguatrib; PaTrin 2; PaTrin2; |
| Protocol | In Vitro | Lomeguatrib (Compound 10) is a O6-methylguanine methyltransferase (MGMT) inhibitor, with an IC50 of 9 nM in cell-free assay and ∼6 nM in MCF-7 cells. Lomeguatrib (10 μM) substantially increases the growth inhibitory effects of temozolomide in MCF-7 cells (D60=10 μM with Lomeguatrib vs 400 μM without). |
|---|---|---|
| In Vivo | Lomeguatrib (20 mg/kg i.p.) completely inactivates MGMT within 2 h, but shows no significant effect on tumor growth in MCF-7 xenografts. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0659 mL | 15.3294 mL | 30.6589 mL | 61.3177 mL |
| 5mM | 0.6132 mL | 3.0659 mL | 6.1318 mL | 12.2635 mL |
| 10mM | 0.3066 mL | 1.5329 mL | 3.0659 mL | 6.1318 mL |
| 20mM | 0.1533 mL | 0.7665 mL | 1.5329 mL | 3.0659 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing DMSO master liquid:
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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