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Bobcat339 HCl

This product is for research use only, not for human use. We do not sell to patients.

Bobcat339 HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1080Check With Us
500mg$1550Check With Us
1g$2325Check With Us
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Cat #: V4930 CAS #: 2280037-51-4 HCl Purity ≥ 98%

Description: Bobcat339 HCl is a novel and potent cytosine-based TET enzyme inhibitor with IC50 of 33 μM (TET1) and 73 μM (TET2).

References: Chua GNL, et al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185.

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Molecular Weight (MW)334.20
Molecular FormulaC16H13Cl2N3O
CAS No.2280037-51-4 HCl
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeO=C1N=C(N)C(Cl)=CN1C2=CC(C3=CC=CC=C3)=CC=C2.[H]Cl
SynonymsBobcat339; Bobcat-339; Bobcat 339; Bobcat339 HCl; Bobcat339 hydrochloride
ProtocolIn VitroBobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.9922 mL14.9611 mL29.9222 mL59.8444 mL
5mM0.5984 mL2.9922 mL5.9844 mL11.9689 mL
10mM0.2992 mL1.4961 mL2.9922 mL5.9844 mL
20mM0.1496 mL0.7481 mL1.4961 mL2.9922 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Concentration(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.