Zebularine (NSC309132; 4-Deoxyuridine)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $950 | Check With Us |
| 1g | $1450 | Check With Us |
| 5g | $2175 | Check With Us |
: Cat #: V0407 CAS #: 3690-10-6 Purity ≥ 98%
Description: Zebularine (formerly 4-Deoxyuridine; NSC-309132) is a selective and potent inhibitor of DNA methylation/methyltransferase with anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 228.2 |
|---|---|
| Molecular Formula | C9H12N2O5 |
| CAS No. | 3690-10-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 46 mg/mL (201.6 mM)r |
| Water: 46 mg/mL (201.6 mM)r | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | Saline: 30 mg/mL |
| SMILES Code | OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=CC=NC2=O)O1 |
| Synonyms | Zebularine; NSC-309132; NSC 309132; NSC309132; 4-Deoxyuridine; 4 Deoxyuridine |
| Protocol | In Vitro | Zebularine exerts its demethylation activity by stabilizing the binding of DNMTs to DNA, hindering the methylation and decreasing the dissociation, thereby trapping the enzyme and preventing turnover even at other sites. zebularine enhances tumor cell chemo- and radiosensitivity and has antimitogenic and angiostatic activities. |
|---|---|---|
| In Vivo | Zebularine is only slightly cytotoxic to tumor-bearing mice. Compared with those in control mice, tumor volumes are statistically significantly reduced in mice treated with high-dose zebularine administered by intraperitoneal injection or by oral gavage. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.3821 mL | 21.9106 mL | 43.8212 mL | 87.6424 mL |
| 5mM | 0.8764 mL | 4.3821 mL | 8.7642 mL | 17.5285 mL |
| 10mM | 0.4382 mL | 2.1911 mL | 4.3821 mL | 8.7642 mL |
| 20mM | 0.2191 mL | 1.0955 mL | 2.1911 mL | 4.3821 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.