RG108
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1275 | Check With Us |
| 1g | $1910 | Check With Us |
: Cat #: V0405 CAS #: 48208-26-0 Purity ≥ 98%
Description: RG108, also known as N-Phthalyl-L-tryptophan, is a novel non-nucleoside inhibitor of DNA methyltransferase ((DNMT) with potential antitumor activity.
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| Molecular Weight (MW) | 334.33 |
|---|---|
| Molecular Formula | C19H14N2O4 |
| CAS No. | 48208-26-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 67 mg/mL (200.4 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: 67 mg/mL (200.4 mM) | |
| SMILES Code | O=C(O)[C@H](CC1=CNC2=CC=CC=C12)N3C(C4=CC=CC=C4C3=O)=O |
| Synonyms | N-Phthalyl-L-tryptophan; RG-108; RG 108; RG108; |
| Protocol | In Vitro | RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines. Incubation of cells with low micromolar concentrations of RG108 results in significant demethylation of genomic DNA without any detectable toxicity. Intriguingly, RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9911 mL | 14.9553 mL | 29.9106 mL | 59.8211 mL |
| 5mM | 0.5982 mL | 2.9911 mL | 5.9821 mL | 11.9642 mL |
| 10mM | 0.2991 mL | 1.4955 mL | 2.9911 mL | 5.9821 mL |
| 20mM | 0.1496 mL | 0.7478 mL | 1.4955 mL | 2.9911 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.