Levetiracetam (UCB-L 059, SIB-S 1)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $350 | Check With Us |
| 5g | $450 | Check With Us |
| 10g | $675 | Check With Us |
: Cat #: V0335 CAS #: 102767-28-2 Purity ≥ 98%
Description: Levetiracetam (also known as UCB-L059, SIB-S1) is a potent and selective M2 muscarinic acetylcholine receptors (mAChR) inhibitor and an anticonvulsant medication used to treat epilepsy.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 170.21 |
|---|---|
| Molecular Formula | C8H14N2O2 |
| CAS No. | 102767-28-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 34 mg/mL (199.8 mM)r |
| Water: 34 mg/mL (199.8 mM)r | |
| Ethanol: 34 mg/mL (199.8 mM) | |
| Solubility In Vivo | Saline: 30 mg/mL |
| SMILES Code | O=C(N)[C@H](CC)N1C(CCC1)=O |
| Synonyms | Levetiracetam, UCBL059, UCB L059, UCB-L059, SIB S1, SIBS1, SIB-S1, Keppra, Etiracetam, UCB6474, UCB-6474, UCB 6474, |
| Protocol | In Vitro | Levetiracetam sensitizes (40 μg/mL) glioblastoma multiforme stem-like cells (GSCs) to Temozolomide (250 µM) treatment. Levetiracetam increases the transcription of HDACs and recruits corepressor complex on O6-Methylguanine-DNA-methyltransferase (MGMT) promoter, thus silencing its activity. MGMT expression is downregulated in GCSCs treated with Levetiracetam (40 μg/mL). |
|---|---|---|
| In Vivo | Levetiracetam (10, 25, or 50 mg/kg) suppresses behavioral and electrographic seizure activity during neonatal hypoxia. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.8751 mL | 29.3755 mL | 58.7510 mL | 117.5019 mL |
| 5mM | 1.1750 mL | 5.8751 mL | 11.7502 mL | 23.5004 mL |
| 10mM | 0.5875 mL | 2.9375 mL | 5.8751 mL | 11.7502 mL |
| 20mM | 0.2938 mL | 1.4688 mL | 2.9375 mL | 5.8751 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.