UNC6852
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1200 | To Be Confirmed |
| 250mg | $1750 | To Be Confirmed |
| 500mg | $2625 | To Be Confirmed |
: Cat #: V40758 CAS #: N/A Purity ≥ 99%
Description: UNC6852 (UNC-6852) is a novel PROTAC-based degrader PRC2 (polycomb repressive complex 2).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 832.97 |
|---|---|
| Molecular Formula | C43H48N10O6S |
| CAS No. | N/A |
| SMILES Code | O=C([C@H]1N(C([C@@H](NC(CCCNC(C2=CC=C(C3=CN=C(NCC4=CC=CO4)N5C3=NN=C5)C=C2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6 |
| Synonyms | UNC6852; UNC-6852; UNC 6852 |
| Protocol | In Vitro | UNC6852 reduces H3K27me3 levels and DLBCL cell proliferation. UNC6852 selectively degrades EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment. UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells. UNC6852 mediates PRC2 degradation. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.2005 mL | 6.0026 mL | 12.0052 mL | 24.0105 mL |
| 5mM | 0.2401 mL | 1.2005 mL | 2.4010 mL | 4.8021 mL |
| 10mM | 0.1201 mL | 0.6003 mL | 1.2005 mL | 2.4010 mL |
| 20mM | 0.0600 mL | 0.3001 mL | 0.6003 mL | 1.2005 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.